The origins of this go back to France’s Catholic King Francis I having contempt for the Catholic Holy Roman Emperor Charles V of Spain.
Francis I did the unimaginable — he made an alliance with the Muslim Ottoman Sultan, Suleiman the Magnificent.
This was the first time a European monarch made such an alliance with a Muslim power, resulting in calls being made for Francis I to be excommunicated.
France and the Ottoman Turkish Empire joined in an alliance, laying siege to Marseille in 1543, bombarding the city of Nice, raiding the Italian coast, and invading Eastern Europe.